Reversal of fortune is a popular theme for many stories. Someone wins the lottery and blows it all. Everything goes right then suddenly you find yourself back to square one. Write a story about your character getting everything that he or she wants only to lose it all overnight.
Why not start the story with your character on cloud nine then watch them crash and burn. Ouch I know that sounds harsh but the best stories are when the characters we love and cherish go through suffering and pain as they take a rough journey through life. That painful journey helps to make them real and helps us the readers share their pain and in return learn to love them.